Histopathological evaluation of dental follicles associated with impacted third molars
Aim: To histologically evaluate dental follicles of impacted third molars with no radiographic evidence of pathology. Methods: We carried out both a quantitative and qualitative analysis of pericoronal follicles removed from impacted third molars and investigated the association with clinical data. The sample included 36 extracted dental follicles of impacted third molars, obtained from 28 patients, which presented with
no radiographic evidence of pathologies. Results: None of the follicles analyzed showed any pathological entity. The epithelial lining was observed in 61.1% of samples, being identified as reduced enamel epithelium. We found a significant relation between the the presence of inflammatory infiltrate and the group aged over 21 years (64.3%; p<0.05). Conclusions: Considering the absence of pathological lesions, we suggest that the removal of impacted third molars, particularly in young-aged individuals, should be carefully indicated.
teeth- a radiographic study in a North Greek population. Med Oral Patol Oral Cir Bucal. 2011;16:e56-61.
2. Kotrashetti VS, Kale AD, Bhalaerao SS, Hallikeremath SR. Histopathologic changes in soft
tissue associated with radiographically normal impacted third molars. Indian J Dent Res.
2010 Jul-Sep;21(3):385-90. doi: 10.4103/0970-9290.70809.
3. Adelsperger J, Campbell JH, Coates DB, Summerlin DJ, Tomich CE. Early soft tissue pathosis
associated with impacted third molars without pericoronal radiolucency. Oral Surg Oral Med Oral
Pathol Oral Radiol Endod. 2000 Apr;89(4):402-6.
4. Marciani RD. Is there pathology associated with asymptomatic third molars? J Oral Maxillofac Surg.
2012 Sep;70(9 Suppl 1):S15-9. doi: 10.1016/j.joms.2012.04.025.
5. Stathopoulos P, Mezitis M, Kappatos C, Titsinides S, Stylogianni E. Cysts and tumors associated with
impacted third molars: is prophylactic removal justified? J Oral Maxillofac Surg. 2011 Feb;69(2):405-8.
6. Brkić A, Mutlu S, Koçak-Berberoğlu H, Olgaç V. Pathological changes and immunoexpression of p63
gene in dental follicles of asymptomatic impacted lower third molars: an immunohistochemical
study. J Craniofac Surg. 2010 May;21(3):854-7. doi: 10.1097/SCS.0b013e3181d809ab.
7. Curran AE, Damm DD, Drummond JF. Pathologically significant pericoronal lesions in adults:
Histopathologic evaluation. J Oral Maxillofac Surg. 2002 Jun;60(6):613-7; discussion 618.
8. van der Linden W, Cleaton-Jones P, Lownie M. Diseases and lesions associated with third molars.
Review of 1001 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Feb;79(2):142-5.
9. Dudhia R, Monsour PA, Savage NW, Wilson RJ. Accuracy of angular measurements and assessment
of distortion in the mandibular third molar region on panoramic radiographs. Oral Surg Oral Med Oral
Pathol Oral Radiol Endod. 2011 Apr;111(4):508-16. doi: 10.1016/j.tripleo.2010.12.005.
10. Simşek-Kaya G, Ozbek E, Kalkan Y, Yapici G, Dayi E, Demirci T. Soft tissue pathosis associated with
asymptomatic impacted lower third molars. Med Oral Patol Oral Cir Bucal. 2011 Nov;16:e929-36.
11. Costa FW, Viana TS, Cavalcante GM, de Barros Silva PG, Cavalcante RB, Nogueira AS et al. A
clinicoradiographic and pathological study of pericoronal follicles associated to mandibular third
molars. J Craniofac Surg. 2014 May;25(3):e283-7. doi: 10.1097/SCS.0000000000000712.
12. Khorasani M, Samiezadeh F. Histopathologic Evaluation of Follicular Tissues Associated with
Impacted Third Molars. J Dent Med Tehran Univ Med Sci. 2008;5:65-70.
13. Villalba L, Stolbizer F, Blasco F, Mauriño NR, Piloni MJ, Keszler A. Pericoronal follicles of
asymptomatic impacted teeth: a radiographic, histomorphologic, and immunohistochemical study.
Int J Dent. 2012;2012:935310. doi: 10.1155/2012/935310.
14. de Paula AM, Carvalhais JN, Domingues MG, Barreto DC, Mesquita RA. Cell proliferation markers in
the odontogenic keratocysts: Effect of inflammation. J Oral Pathol Med. 2000 Nov;29:477-82.
15. Kumar V, Abbas AK, Fausto N. Robbins and Cotran. Pathologic Basis of Disease. 7th ed. Philadelphia:
16. Kim J, Ellis GL. Dental folliculartissue: misinterpretation as odontogenictumors. J Oral Maxillofac
Surg. 1993 Jul;51(7):762-7.
This work is licensed under a Creative Commons Attribution 4.0 International License.
- All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY. The online journal is free and open access.