Analysis of IL-10 in HIV-1 patients with chronic periodontitis in northern Brazil

  • Silvio Augusto Fernandes de Menezes
  • Tatiany Oliveira de Alencar Menezes
  • Tânia Maria de Souza Rodrigues
  • Brenna Magdalena Lima Nogueira
  • Ricardo Roberto de Souza Fonseca


Aim: The objective of this study was to investigate the levels of IL-10 in the gingival crevicular fluid in HIV-1 positive patients with chronic periodontitis and to compare with HIV-1 negative patients with chronic periodontitis, also to correlate clinical periodontal parameters, viral load and count of CD4 + and CD8 + lymphocytes (LTCD4 + and LTCD8 +). Methods: 33 patients were selected and splitted into two groups: 16 HIV-1 positive patients and 17 HIV-1 negative patients and all with chronic periodontitis. The clinical periodontal parameters recorded were: Probing Depth (PD) and Clinical Attachment Level (CAL); the sistemical parameters LTCD4 +, LTCD8 + and viral load were analized by the gingival crevicular fluid collected from all patients. Enzymelinked immunosorbent assay (ELISA) was used to determine the concentrations of Interleukin (IL)-10. For the statistical analysis the Student t, Mann-Whitney and Spearman tests were performed. IL-10 levels were significantly lower in both patients groups. Results: There was statistical difference betwen groups for probing depth (p=0.015) and clinical attachment level (p=0.011), no significant correlation was found among the analyzed variables. Conclusion: The IL-10 levels in HIV-1 positive patients had no influence in periodontal and medical parameters.


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How to Cite
DE MENEZES, Silvio Augusto Fernandes et al. Analysis of IL-10 in HIV-1 patients with chronic periodontitis in northern Brazil. Brazilian Journal of Oral Sciences, [S.l.], p. e17072, oct. 2017. ISSN 1677-3225. Available at: <>. Date accessed: 16 july 2019. doi:
Original Research