FORMAÇÃO

Cirurgião Dentista (FOP-UNICAMP, 1994); Mestre (FOP-UNICAMP, 1996); Doutor com Estágio Sanduíche de 12 meses junto a University of Maryland Dental School (FOP-UNICAMP, 1999); Pós-Doutoramento (University of Colorado School of Medicine, 2002-2004); Professor Associado (FOP-UNICAMP, 2006).

ÁREAS DE INTERESSE

O interesse de nosso laboratório poder ser dividido em 3 Áreas:

• Compreender os mecanismos biológicos e genéticos relacionados ao câncer de boca, particularmente entender a participação dos genes homeobox na tumorigênese oral e determinar a influência dos miofibroblastos do estroma tumoral nos fenótipos relacionados ao câncer, incluindo proliferação e invasão celular.
• Analisar os aspectos clínicos, epidemiológicos, genéticos e moleculares das doenças genéticas e síndromes com envolvimento orofacial, com particular ênfase ao estudo de polimorfismos genéticos em fissuras lábio-palatinas.
• Caracterizar os mecanismos biológicos e determinar os defeitos genéticos dos aumentos gengivais induzidos por ciclosporina A e os herdados como fibromatose gengival. Em um futuro próximo identificar moléculas e terapias definitivas para os aumentos gengivais.

PUBLICAÇÕES SELECIONADAS

• Seguin F, Carvalho MA, Bastos DC, Agostini M, Zecchin KG, Alvarez-Flores MP, Chudzinski-Tavassi AM, Coletta RD, Graner E. The fatty acid synthase inhibitor orlistat reduces experimental metastases and angiogenesis in B16-F10 melanomas. Br J Cancer. 2012 Sep 4;107(6):977-87.
• Aragão AZ, Belloni M, Simabuco FM, Zanetti MR, Yokoo S, Domingues RR, Kawahara R, Pauletti BA, Gonçalves A, Agostini M, Graner E, Coletta RD, Fox JW, Leme AF. Novel Processed Form of Syndecan-1 Shed from SCC-9 Cells Plays a Role in Cell Migration. PLoS One. 2012;7(8):e43521.
• Sobral, LM, Aseredo F, Agostini M; Bufalino A; Pereira MCC; Graner E; Coletta, RD. Molecular events associated with ciclosporin A-induced gingival overgrowth are attenuated by Smad7 overexpression in fibroblasts. Journal of Periodontal Research, v. 47, p. 149-158, 2012.
• Bitu C, Carrera M, Lopes MA, Kowalski LP, Soares FA, Coletta RD. HOXB7 expression is a prognostic factor for oral squamous cell carcinoma. Histopathology (Oxford. Print), v. 60, p. 662-665, 2012.
• Bufalino A, Paranaíba LMR, Gouvêa AF, Gueiros LA, Martelli-Júnior H, Junior JJ, Lopes MA, Graner E, Almeida OP, Vargas PA, Coletta RD. Cleidocranial dysplasia: oral features and genetic analysis of 11 patients. Oral Diseases, v. 18, p. 184-190, 2012.
• Bitu C, Destro MF, Carrera M, Silva S, Graner E, Kowalski  LP, Soares F, Coletta R. HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis. BMC Cancer, v. 12, p. 146, 2012.
• SOBRAL LM; Zecchin KG; AQUINO SN; LOPES MA; GRANER E; COLETTA RD. Isolation and characterization of myofibroblast cell lines from oral squamous cell carcinoma. Oncology Reports, v. 25, p. 1013-1020, 2011.
• PARANAIBA LM, BUFALINO A; Martelli-Júnior Hercílio; BARROS LM; GRANER E; COLETTA RD. Lack of Association Between IRF6 Polymorphisms (rs2235371 and rs642961) and Nonsyndromic Cleft Lip and/or Palate in a Brazilian Population. Oral Diseases, v. 16, p. 193-197, 2010.
• DESTRO MFSS; BITU CC; Zecchin KG; GRANER E; LOPES MA; COLETTA RD. Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. International Journal of Oncology, v. 36, p. 141-149, 2010.
• Bufalino A; Ribeiro Paranaíba LM; Nascimento de Aquino S; Martelli-Júnior H; Oliveira Swerts MS; Coletta RD. Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population. Birth Defects Research. Clinical and Molecular Teratology, v. 88, p. 980-986, 2010.
• Sobral LM; Montan PF; Zecchin KG; Martelli-Junior H; Vargas PA; Graner E; Coletta RD. Smad7 Blocks Transforming Growth Factor-beta1-Induced Gingival Fibroblast-Myofibroblast Transition via Inhibitory Regulation of Smad2 and Connective Tissue Growth Factor. Journal of Periodontology (1970), v. 82, p. 642-651, 2010.
• Micalizzi DS; Christensen KL; Jedlicka P; Coletta RD; Barón AE; Harrell JC; Horwitz KB; Billheimer D; Heichman KA; Welm AL; Schiemann WP; Ford HL. The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. The Journal of Clinical Investigation, v. 119, p. 2678-2690, 2009.
• KELLERMANN MG; SOBRAL LM; SILVA SD; ZECCHIN KG; GRANER E; LOPES MA; KOWALSKI LP; COLETTA RD. Mutual paracrine effects of oral squamous cell carcinoma cells and normal oral fibroblasts: induction of fibroblast to myofibroblast transdifferentiation and modulation of tumor cell proliferation. Oral Oncology, v. 44, p. 509-517, 2008.
• PARANAIBA LM; MARTELLI JUNIOR H; SWERTS MSO; LINE S; COLETTA RD . Novel mutations in the IRF6 gene in Brazilian families with Van der Woude syndrome. International Journal of Molecular Medicine, v. 22, p. 507-511, 2008.
• COLETTA RD; Christensen KL; MICALIZZI DS; JEDLICKA P; VARELLA-GARCIA M; FORD HL. Six1 Overexpression in Mammary Cells Induces Genomic Instability and Is Sufficient for Malignant Transformation. Cancer Research, v. 68, p. 2204-2213, 2008.
• SOBRAL LM; MONTAN PF; MARTELLI JUNIOR H; GRANER E; COLETTA RD. Opposite effects of TGF-beta1 and IFN-gama on transdifferentiation of myofibroblast in human gingival cell cultures. Journal of Clinical Periodontology, v. 34, p. 397-406, 2007.
• KELLERMANN MG ; SOBRAL LM; SILVA SD; ZECCHIN K; GRANER E; LOPES MA; NISHIMOTO I; KOWALSKI LP; COLETTA RD. Myofibroblasts in the stroma of oral squamous cell carcinoma are associated with poor prognosis. Histopathology, v. 51, p. 849-853, 2007.
• BITU CC; SOBRAL LM; KELLERMANN MG; MARTELLI JUNIOR H; ZECCHIN KG; GRANER E; COLETTA RD. Heterogeneous presence of myofibroblasts in hereditary gingival fibromatosis. Journal of Clinical Periodontology, v. 33, n. 6, p. 393-400, 2006.
• MILLER M; WANG C; PARISINI E; COLETTA RD; GOTO R; LEE S; BARRAL D; TOWNES M; ROURA-MIR C; FORD HL. Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family. PNAS. Proceedings of the National Academy of Sciences of the United States of America, v. 102, n. 24, p. 8674-8679, 2005.
• COLETTA RD; JEDLICKA P; GUTIERREZ-HARTMANN A; FORD HL. Transcriptional control of the cell cycle in mammary gland development and tumorigenesis. Journal of Mammary Gland Biology and Neoplasia, v. 9, p. 39-53, 2004.
• COLETTA RD; CHRISTENSEN K; REICHENBERGER KJ; LAMB J; MICOMONACO D; HUANG L; WOLF DM; MULLER-TIDOW C; KAWAKAMI K; FORD HL. The Six1 homeoprotein stimulates tumorigenesis via reactivation of the germ line and embryonic specific cyclin A1. PNAS. Proceedings of the National Academy of Sciences of the United States of America, v. 101, p. 6478-6483, 2004.